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High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design
The crystal structure of human carbonic anhydrase II (CA II) complexed with the inhibitor acetazolamide (AZM) has been determined at 1.1 Å resolution and refined to an R (cryst) of 11.2% and an R (free) of 14.7%. As observed in previous CA II–inhibitor complexes, AZM binds directly to the zinc and m...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Union of Crystallography
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765883/ https://ncbi.nlm.nih.gov/pubmed/19851004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109036665 |
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