A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 Å resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the ob...

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Hauptverfasser: Avvaru, Balendu Sankara, Kim, Chae Un, Sippel, Katherine H., Gruner, Sol M., Agbandje-McKenna, Mavis, Silverman, David N., McKenna, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810610/
https://ncbi.nlm.nih.gov/pubmed/20000378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902007b
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