Tracking solvent and protein movement during CO(2) release in carbonic anhydrase II crystals

Carbonic anhydrases are mostly zinc metalloenzymes that catalyze the reversible hydration/dehydration of CO(2)/HCO(3)(−). Previously, the X-ray crystal structures of CO(2)-bound holo (zinc-bound) and apo (zinc-free) human carbonic anhydrase IIs (hCA IIs) were captured at high resolution. Here, we pr...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kim, Chae Un, Song, HyoJin, Avvaru, Balendu Sankara, Gruner, Sol M., Park, SangYoun, McKenna, Robert
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868437/
https://ncbi.nlm.nih.gov/pubmed/27114542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520786113
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