Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability and Solvent Network,

Human carbonic anhydrase II (HCA II) is a monomeric zinc-containing metalloenzyme that catalyzes the hydration of CO(2) to form bicarbonate and a proton. The properties of the zinc have been extensively elucidated in catalysis, but less well studied as a contributor to structure and stability. Apo-H...

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Bibliographic Details
Main Authors: Avvaru, Balendu Sankara, Busby, Scott A., Chalmers, Michael J., Griffin, Patrick R., Venkatakrishnan, Balasubramanian, Agbandje-McKenna, Mavis, Silverman, David N., McKenna, Robert
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762735/
https://ncbi.nlm.nih.gov/pubmed/19583303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9007512
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