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Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms

The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC) activation and liver fibrosis, we sought to determine the role of synectin on the PDGFR...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JCI Insight
Main Authors: Drinane, Mary C., Yaqoob, Usman, Yu, Haibin, Luo, Fanghong, Greuter, Thomas, Arab, Juan P., Kostallari, Enis, Verma, Vikas K., Maiers, Jessica, De Assuncao, Thiago Milech, Simons, Michael, Mukhopadhyay, Debabrata, Kisseleva, Tatiana, Brenner, David A., Urrutia, Raul, Lomberk, Gwen, Gao, Yandong, Ligresti, Giovanni, Tschumperlin, Daniel J., Revzin, Alexander, Cao, Sheng, Shah, Vijay H.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752303/
https://ncbi.nlm.nih.gov/pubmed/29263300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92821
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