Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms

The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC) activation and liver fibrosis, we sought to determine the role of synectin on the PDGFR...

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Publicado en:JCI Insight
Autores principales: Drinane, Mary C., Yaqoob, Usman, Yu, Haibin, Luo, Fanghong, Greuter, Thomas, Arab, Juan P., Kostallari, Enis, Verma, Vikas K., Maiers, Jessica, De Assuncao, Thiago Milech, Simons, Michael, Mukhopadhyay, Debabrata, Kisseleva, Tatiana, Brenner, David A., Urrutia, Raul, Lomberk, Gwen, Gao, Yandong, Ligresti, Giovanni, Tschumperlin, Daniel J., Revzin, Alexander, Cao, Sheng, Shah, Vijay H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752303/
https://ncbi.nlm.nih.gov/pubmed/29263300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92821
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