Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms

The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC) activation and liver fibrosis, we sought to determine the role of synectin on the PDGFR...

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Publicat a:JCI Insight
Autors principals: Drinane, Mary C., Yaqoob, Usman, Yu, Haibin, Luo, Fanghong, Greuter, Thomas, Arab, Juan P., Kostallari, Enis, Verma, Vikas K., Maiers, Jessica, De Assuncao, Thiago Milech, Simons, Michael, Mukhopadhyay, Debabrata, Kisseleva, Tatiana, Brenner, David A., Urrutia, Raul, Lomberk, Gwen, Gao, Yandong, Ligresti, Giovanni, Tschumperlin, Daniel J., Revzin, Alexander, Cao, Sheng, Shah, Vijay H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752303/
https://ncbi.nlm.nih.gov/pubmed/29263300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92821
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