Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms

The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC) activation and liver fibrosis, we sought to determine the role of synectin on the PDGFR...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Drinane, Mary C., Yaqoob, Usman, Yu, Haibin, Luo, Fanghong, Greuter, Thomas, Arab, Juan P., Kostallari, Enis, Verma, Vikas K., Maiers, Jessica, De Assuncao, Thiago Milech, Simons, Michael, Mukhopadhyay, Debabrata, Kisseleva, Tatiana, Brenner, David A., Urrutia, Raul, Lomberk, Gwen, Gao, Yandong, Ligresti, Giovanni, Tschumperlin, Daniel J., Revzin, Alexander, Cao, Sheng, Shah, Vijay H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752303/
https://ncbi.nlm.nih.gov/pubmed/29263300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92821
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker