The UPR mediates fibrogenesis and collagen I secretion through regulating TANGO1

BACKGROUND/AIMS: Fibrogenesis encompasses the deposition of matrix proteins such as collagen I by hepatic stellate cells (HSCs) that culminates in cirrhosis. Fibrogenic signals drive transcription of procollagen I, which enters the endoplasmic reticulum (ER), is trafficked through the secretory path...

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Publicado en:Hepatology
Autores principales: Maiers, Jessica L, Kostallari, Enis, Mushref, Malek, de Assuncao, Thiago M, Li, Haiyang, Huebert, Robert C, Cao, Sheng, Malhi, Harmeet, Shah, Vijay H
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319908/
https://ncbi.nlm.nih.gov/pubmed/28039913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28921
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