Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice

Liver injury and the unfolded protein response (UPR) are tightly linked, but their relationship differs with cell type and injurious stimuli. UPR initiation promotes hepatic stellate cell (HSC) activation and fibrogenesis, but the underlying mechanisms are unclear. Despite the complexity and overlap...

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Détails bibliographiques
Publié dans:Am J Physiol Gastrointest Liver Physiol
Auteurs principaux: Xue, Fei, Lu, Jianwen, Buchl, Samuel C., Sun, Liankang, Shah, Vijay H., Malhi, Harmeet, Maiers, Jessica L.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202196/
https://ncbi.nlm.nih.gov/pubmed/33728997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00453.2020
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