Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma

Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1α correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8. Si...

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Detalhes bibliográficos
Main Authors: Auf, Gregor, Jabouille, Arnaud, Guérit, Sylvaine, Pineau, Raphaël, Delugin, Maylis, Bouchecareilh, Marion, Magnin, Noël, Favereaux, Alexandre, Maitre, Marlène, Gaiser, Timo, von Deimling, Andreas, Czabanka, Marcus, Vajkoczy, Peter, Chevet, Eric, Bikfalvi, Andreas, Moenner, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932600/
https://ncbi.nlm.nih.gov/pubmed/20702765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914072107
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