The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A

BACKGROUND: Amifostine (WR-2721, delivered as Ethyol(®)) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without reducing their efficacy on tumour cells. Its mechanism of action is attribute...

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Detalhes bibliográficos
Main Authors: Dedieu, S, Canron, X, Rezvani, HR, Bouchecareilh, M, Mazurier, F, Sinisi, R, Zanda, M, Moenner, M, Bikfalvi, A, North, S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859403/
https://ncbi.nlm.nih.gov/pubmed/20334641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-8-19
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