Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice

Liver injury and the unfolded protein response (UPR) are tightly linked, but their relationship differs with cell type and injurious stimuli. UPR initiation promotes hepatic stellate cell (HSC) activation and fibrogenesis, but the underlying mechanisms are unclear. Despite the complexity and overlap...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Xue, Fei, Lu, Jianwen, Buchl, Samuel C., Sun, Liankang, Shah, Vijay H., Malhi, Harmeet, Maiers, Jessica L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202196/
https://ncbi.nlm.nih.gov/pubmed/33728997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00453.2020
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