Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate–Induced Cell Migration

Dynamin-2 (Dyn2) is implicated in endocytosis of receptor tyrosine kinases, which contribute to hepatic stellate cell (HSC) activation and liver fibrosis. A point mutation converting lysine 44 of Dyn2 to alanine (Dyn2K44A) disrupts its GTPase activity. We hypothesized that Dyn2K44A expression in HSC...

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Publicado en:Am J Pathol
Autores principales: Wang, Ruisi, Ding, Qian, De Assuncao, Thiago M., Mounajjed, Taofic, Maiers, Jessica L., Dou, Changwei, Cao, Sheng, Yaqoob, Usman, Huebert, Robert C., Shah, Vijay H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2017
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225297/
https://ncbi.nlm.nih.gov/pubmed/27840081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.09.001
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