Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV), which is associated with AscAA. Here, we describe a potentially novel role for Notch1 in AscAA. We found that Notch1 hap...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Koenig, Sara N., LaHaye, Stephanie, Feller, James D., Rowland, Patrick, Hor, Kan N., Trask, Aaron J., Janssen, Paul M.L., Radtke, Freddy, Lilly, Brenda, Garg, Vidu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752295/
https://ncbi.nlm.nih.gov/pubmed/29093270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91353
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker