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Notch1 haploinsufficiency causes ascending aortic aneurysms in mice
An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV), which is associated with AscAA. Here, we describe a potentially novel role for Notch1 in AscAA. We found that Notch1 hap...
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| Pubblicato in: | JCI Insight |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752295/ https://ncbi.nlm.nih.gov/pubmed/29093270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91353 |
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