Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV), which is associated with AscAA. Here, we describe a potentially novel role for Notch1 in AscAA. We found that Notch1 hap...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Koenig, Sara N., LaHaye, Stephanie, Feller, James D., Rowland, Patrick, Hor, Kan N., Trask, Aaron J., Janssen, Paul M.L., Radtke, Freddy, Lilly, Brenda, Garg, Vidu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752295/
https://ncbi.nlm.nih.gov/pubmed/29093270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91353
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