Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopathy in humans. The aim of this study was to determ...

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Bibliographic Details
Published in:	J Cardiovasc Dev Dis
Main Authors:	Koenig, Sara N., Bosse, Kevin M., Nadorlik, Holly A., Lilly, Brenda, Garg, Vidu
Format:	Artigo
Language:	Inglês
Published:	MDPI 2015
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4407710/ https://ncbi.nlm.nih.gov/pubmed/25914885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcdd2010017
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Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

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