Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression

AIMS: Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we demonstrated that global Notch1 deficiency prevents the formation of AAA in a mouse model. Herein, we sought to explore the cell-specific...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Sachdeva, Jaspreet, Mahajan, Advitiya, Cheng, Jeeyun, Baeten, Jeremy T., Lilly, Brenda, Kuivaniemi, Helena, Hans, Chetan P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451061/
https://ncbi.nlm.nih.gov/pubmed/28562688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178538
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