Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model

BACKGROUND: The progression of abdominal aortic aneurysm (AAA) involves a sustained influx of proinflammatory macrophages, which exacerbate tissue injury by releasing cytokines, chemokines, and matrix metalloproteinases. Previously, we showed that Notch deficiency reduces the development of AAA in t...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Cheng, Jeeyun, Koenig, Sara N., Kuivaniemi, Helena S., Garg, Vidu, Hans, Chetan P.
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338693/
https://ncbi.nlm.nih.gov/pubmed/25349182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001064
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