Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation

OBJECTIVE: Activation of inflammatory pathways plays a critical role in the development of abdominal aortic aneurysms (AAA). Notch1 signaling is a significant regulator of the inflammatory response; however, its role in AAA is unknown. METHODS AND RESULTS: In an angiotensin II (AngII)-induced mouse...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Hans, Chetan P., Koenig, Sara N., Huang, Nianyuan, Cheng, Jeeyun, Beceiro, Susana, Guggilam, Anuradha, Kuivaniemi, Helena, Partida-Sánchez, Santiago, Garg, Vidu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467024/
https://ncbi.nlm.nih.gov/pubmed/23087364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.254219
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