Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression

AIMS: Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we demonstrated that global Notch1 deficiency prevents the formation of AAA in a mouse model. Herein, we sought to explore the cell-specific...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sachdeva, Jaspreet, Mahajan, Advitiya, Cheng, Jeeyun, Baeten, Jeremy T., Lilly, Brenda, Kuivaniemi, Helena, Hans, Chetan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451061/
https://ncbi.nlm.nih.gov/pubmed/28562688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178538
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