The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion

Primary and secondary hypertension are major risk factors for cardiovascular disease, the leading cause of death worldwide. Elevated secretion of aldosterone resulting from primary aldosteronism (PA) is a key driver of secondary hypertension. Here, we report an unexpected role for the ubiquitin liga...

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Vydáno v:JCI Insight
Hlavní autoři: Scortegagna, Marzia, Berthon, Annabel, Settas, Nikolaos, Giannakou, Andreas, Garcia, Guillermina, Li, Jian-Liang, James, Brian, Liddington, Robert C., Vilches-Moure, José G., Stratakis, Constantine A., Ronai, Ze’ev A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752272/
https://ncbi.nlm.nih.gov/pubmed/29212953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97128
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