USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains

The RING finger E3 ubiquitin ligase Siah2 is implicated in control of diverse cellular biological events, including MAPK signaling and hypoxia. Here we demonstrate that Siah2 is subject to regulation by the deubiquitinating enzyme USP13. Overexpression of USP13 increases Siah2 stability by attenuati...

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Detalhes bibliográficos
Main Authors: Scortegagna, Marzia, Subtil, Tony, Qi, Jianfei, Kim, Hyungsoo, Zhao, Wenhui, Gu, Wei, Kluger, Harriet, Ronai, Ze'ev A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149327/
https://ncbi.nlm.nih.gov/pubmed/21659512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218214
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