The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion

Primary and secondary hypertension are major risk factors for cardiovascular disease, the leading cause of death worldwide. Elevated secretion of aldosterone resulting from primary aldosteronism (PA) is a key driver of secondary hypertension. Here, we report an unexpected role for the ubiquitin liga...

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Библиографические подробности
Опубликовано в: :JCI Insight
Главные авторы: Scortegagna, Marzia, Berthon, Annabel, Settas, Nikolaos, Giannakou, Andreas, Garcia, Guillermina, Li, Jian-Liang, James, Brian, Liddington, Robert C., Vilches-Moure, José G., Stratakis, Constantine A., Ronai, Ze’ev A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752272/
https://ncbi.nlm.nih.gov/pubmed/29212953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97128
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