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Orthopaedic Wear Particle-induced Bone Loss and Exogenous Macrophage Infiltration is mitigated by Local Infusion of NF-κB Decoy Oligodeoxynucleotide

Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF-κB. We previously dem...

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Detalhes bibliográficos
Publicado no:J Biomed Mater Res A
Main Authors: Lin, Tzuhua, Pajarinen, Jukka, Nabeshima, Akira, Córdova, Luis A., Loi, Florence, Gibon, Emmanuel, Lu, Laura, Nathan, Karthik, Jämsen, Eemeli, Yao, Zhenyu, Goodman, Stuart B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748269/
https://ncbi.nlm.nih.gov/pubmed/28782280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.36169
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