Orthopaedic Wear Particle-induced Bone Loss and Exogenous Macrophage Infiltration is mitigated by Local Infusion of NF-κB Decoy Oligodeoxynucleotide

Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF-κB. We previously dem...

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Veröffentlicht in:J Biomed Mater Res A
Hauptverfasser: Lin, Tzuhua, Pajarinen, Jukka, Nabeshima, Akira, Córdova, Luis A., Loi, Florence, Gibon, Emmanuel, Lu, Laura, Nathan, Karthik, Jämsen, Eemeli, Yao, Zhenyu, Goodman, Stuart B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748269/
https://ncbi.nlm.nih.gov/pubmed/28782280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.36169
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