NF-κB Decoy Oligodeoxynucleotide Mitigates Wear Particle-Associated Bone Loss in the Murine Continuous Infusion Model

Total joint replacement is a cost-effective surgical procedure for patients with end-stage arthritis. Wear particle-induced chronic inflammation is associated with the development of periprosthetic osteolysis. Modulation of NF-κB signaling in macrophages, osteoclasts, and mesenchymal stem cells coul...

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Veröffentlicht in:Acta Biomater
Hauptverfasser: Lin, Tzu-hua, Pajarinen, Jukka, Sato, Taishi, Loi, Florence, Fan, Changchun, Córdova, Luis A., Nabeshima, Akira, Gibon, Emmanuel, Zhang, Ruth, Yao, Zhenyu, Goodman, Stuart B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969187/
https://ncbi.nlm.nih.gov/pubmed/27260104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.05.038
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