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NF-κB decoy oligodeoxynucleotide inhibits wear particle-induced inflammation in a murine calvarial model

Wear particles induce periprosthetic inflammation and osteolysis through activation of nuclear factor kappa B (NF-κB), which up-regulates the downstream target gene expression for proinflammatory cytokines in macrophages. It was hypothesized that direct suppression of NF-κB activity in the early pha...

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Detalhes bibliográficos
Publicado no:J Biomed Mater Res A
Main Authors: Sato, Taishi, Pajarinen, Jukka, Lin, Tzu-hua, Tamaki, Yasunobu, Loi, Florence, Egashira, Kensuke, Yao, Zhenyu, Goodman, Stuart B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817851/
https://ncbi.nlm.nih.gov/pubmed/26123702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.35532
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