Therapeutic targeting of TAZ and YAP by dimethyl fumarate in systemic sclerosis fibrosis

Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera(®)) have shown therapeutic effects in several disease models, prompting us to determine whether DMF is effective as a treatment for SSc...

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Publicat a:J Invest Dermatol
Autors principals: Toyama, Tetsuo, Looney, Agnieszka P., Baker, Brendon M., Stawski, Lukasz, Haines, Paul, Simms, Robert, Szymaniak, Aleksander D., Varelas, Xaralabos, Trojanowska, Maria
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742036/
https://ncbi.nlm.nih.gov/pubmed/28870693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.08.024
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