Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism

Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation. The lectin pathway of the complement system is initiated by mannose-binding lectin (MBL)-associated S...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Oroszlán, Gábor, Dani, Ráhel, Szilágyi, András, Závodszky, Péter, Thiel, Steffen, Gál, Péter, Dobó, József
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741598/
https://ncbi.nlm.nih.gov/pubmed/29326707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01821
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