Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1

Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1-inhibitor deficiency. Plasma kallikrein, activated by factor XIIa, is responsible for most of HK cleavage. However other proteas...

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Detalhes bibliográficos
Main Authors: Dobó, József, Major, Balázs, Kékesi, Katalin A., Szabó, István, Megyeri, Márton, Hajela, Krishnan, Juhász, Gábor, Závodszky, Péter, Gál, Péter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100311/
https://ncbi.nlm.nih.gov/pubmed/21625439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020036
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