Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

The lectin pathway of complement activation is an important component of the innate immune defense. The initiation complexes of the lectin pathway consist of a recognition molecule and associated serine proteases. Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)-...

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Detalhes bibliográficos
Main Authors: Héja, Dávid, Kocsis, Andrea, Dobó, József, Szilágyi, Katalin, Szász, Róbert, Závodszky, Péter, Pál, Gábor, Gál, Péter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387078/
https://ncbi.nlm.nih.gov/pubmed/22691502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202588109
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