MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked

MASP-3 was discovered 15 years ago as the third mannan-binding lectin (MBL)-associated serine protease of the complement lectin pathway. Lacking any verified substrate its role remained ambiguous. MASP-3 was shown to compete with a key lectin pathway enzyme MASP-2 for MBL binding, and was therefore...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dobó, József, Szakács, Dávid, Oroszlán, Gábor, Kortvely, Elod, Kiss, Bence, Boros, Eszter, Szász, Róbert, Závodszky, Péter, Gál, Péter, Pál, Gábor
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989169/
https://ncbi.nlm.nih.gov/pubmed/27535802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31877
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