Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have been thought to autoactivate when MBL/ficolin·MASP complexes bind to pathogens triggering the complement lectin pathway. Autoactivation of MASPs occurs in two steps: 1) zymogen autoactivation, when one proenzyme cleaves...

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Detalhes bibliográficos
Main Authors: Megyeri, Márton, Harmat, Veronika, Major, Balázs, Végh, Ádám, Balczer, Júlia, Héja, Dávid, Szilágyi, Katalin, Datz, Dániel, Pál, Gábor, Závodszky, Péter, Gál, Péter, Dobó, József
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610966/
https://ncbi.nlm.nih.gov/pubmed/23386610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446500
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