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Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway
Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have been thought to autoactivate when MBL/ficolin·MASP complexes bind to pathogens triggering the complement lectin pathway. Autoactivation of MASPs occurs in two steps: 1) zymogen autoactivation, when one proenzyme cleaves...
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Autors principals: | , , , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610966/ https://ncbi.nlm.nih.gov/pubmed/23386610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446500 |
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