Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

The lectin pathway is an antibody-independent activation route of the complement system. It provides immediate defense against pathogens and altered self-cells, but it also causes severe tissue damage after stroke, heart attack, and other ischemia reperfusion injuries. The pathway is triggered by ta...

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Detalhes bibliográficos
Main Authors: Héja, Dávid, Harmat, Veronika, Fodor, Krisztián, Wilmanns, Matthias, Dobó, József, Kékesi, Katalin A., Závodszky, Péter, Gál, Péter, Pál, Gábor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370211/
https://ncbi.nlm.nih.gov/pubmed/22511776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354332
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