Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)(n) repeats in Friedreich's ataxia, (CTG)(n) repeats in myotonic dystrophy, and (CGG)(n) repeat...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: McGinty, Ryan J., Rubinstein, Rachel G., Neil, Alexander J., Dominska, Margaret, Kiktev, Denis, Petes, Thomas D., Mirkin, Sergei M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741057/
https://ncbi.nlm.nih.gov/pubmed/29113982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228148.117
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