Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)(n) repeats in Friedreich's ataxia, (CTG)(n) repeats in myotonic dystrophy, and (CGG)(n) repeat...

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Détails bibliographiques
Publié dans:Genome Res
Auteurs principaux: McGinty, Ryan J., Rubinstein, Rachel G., Neil, Alexander J., Dominska, Margaret, Kiktev, Denis, Petes, Thomas D., Mirkin, Sergei M.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2017
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Method
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741057/
https://ncbi.nlm.nih.gov/pubmed/29113982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228148.117
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