Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)(n) repeats in Friedreich's ataxia, (CTG)(n) repeats in myotonic dystrophy, and (CGG)(n) repeat...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: McGinty, Ryan J., Rubinstein, Rachel G., Neil, Alexander J., Dominska, Margaret, Kiktev, Denis, Petes, Thomas D., Mirkin, Sergei M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741057/
https://ncbi.nlm.nih.gov/pubmed/29113982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228148.117
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