Excess translation of epigenetic regulators contributes to Fragile X Syndrome and is alleviated by Brd4 inhibition

Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism. FXS results from the loss of function of Fragile X Mental Retardation Protein (FMRP), which represses translation of target transcripts. Most of the well-characterized target transcripts of FMRP are synaptic p...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Korb, Erica, Herre, Margaret, Zucker-Scharff, Ilana, Gresack, Jodi, Allis, C. David, Darnell, Robert B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740873/
https://ncbi.nlm.nih.gov/pubmed/28823556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.033
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