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Excess translation of epigenetic regulators contributes to Fragile X Syndrome and is alleviated by Brd4 inhibition
Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism. FXS results from the loss of function of Fragile X Mental Retardation Protein (FMRP), which represses translation of target transcripts. Most of the well-characterized target transcripts of FMRP are synaptic p...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740873/ https://ncbi.nlm.nih.gov/pubmed/28823556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.033 |
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