Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress

Polymyxins are a last line of defense against multidrug-resistant Gram-negative pathogens. Recent pharmacological data show that intravenous polymyxins can cause nephrotoxicity in up to 60% of patients, and the plasma concentrations of polymyxins achieved with the currently recommended dosage regime...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Azad, Mohammad A. K., Sivanesan, Sivashangarie, Wang, Jiping, Chen, Ke, Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740332/
https://ncbi.nlm.nih.gov/pubmed/29061752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01254-17
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