Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis

Drug efflux pumps play important roles in intrinsic and acquired drug resistance. Verapamil, an efflux inhibitor that enhances the activity of bedaquiline, clofazimine, and other drugs against Mycobacterium tuberculosis, has been proposed as a potential adjunctive agent for treatment of tuberculosis...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Xu, Jian, Tasneen, Rokeya, Peloquin, Charles A., Almeida, Deepak V., Li, Si-Yang, Barnes-Boyle, Kala, Lu, Yu, Nuermberger, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740328/
https://ncbi.nlm.nih.gov/pubmed/29038265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-17
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