Dose-Ranging Comparison of Rifampin and Rifapentine in Two Pathologically Distinct Murine Models of Tuberculosis

In previous experiments, replacing the 10-mg/kg of body weight daily dose of rifampin with 7.5 to 10 mg/kg of rifapentine in combinations containing isoniazid and pyrazinamide reduced the duration of treatment needed to cure tuberculosis in BALB/c mice by approximately 50% due to rifapentine's...

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Main Authors: Rosenthal, Ian M., Tasneen, Rokeya, Peloquin, Charles A., Zhang, Ming, Almeida, Deepak, Mdluli, Khisimuzi E., Karakousis, Petros C., Grosset, Jacques H., Nuermberger, Eric L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421552/
https://ncbi.nlm.nih.gov/pubmed/22664964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00912-12
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