Treatment-Shortening Effect of a Novel Regimen Combining Clofazimine and High-Dose Rifapentine in Pathologically Distinct Mouse Models of Tuberculosis

Clofazimine and high-dose rifapentine have each separately been associated with treatment-shortening activity when incorporated into tuberculosis (TB) treatment regimens. We hypothesized that both modifications, i.e., the addition of clofazimine and the replacement of rifampin with high-dose rifapen...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Saini, Vikram, Ammerman, Nicole C., Chang, Yong Seok, Tasneen, Rokeya, Chaisson, Richard E., Jain, Sanjay, Nuermberger, Eric, Grosset, Jacques H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535519/
https://ncbi.nlm.nih.gov/pubmed/30936097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00388-19
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