Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens conta...

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Bibliografiske detaljer
Main Authors: Nuermberger, Eric, Tyagi, Sandeep, Tasneen, Rokeya, Williams, Kathy N., Almeida, Deepak, Rosenthal, Ian, Grosset, Jacques H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292539/
https://ncbi.nlm.nih.gov/pubmed/18285479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00074-08
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