Paradoxical Effect of Isoniazid on the Activity of Rifampin-Pyrazinamide Combination in a Mouse Model of Tuberculosis

To investigate the antagonism between isoniazid (INH) and rifampin (rifampicin) (RIF)-pyrazinamide (PZA) combination observed in Mycobacterium tuberculosis-infected mice, extensive pharmacokinetic studies of INH were performed and followed by experiments to assess the impact of increasing doses of I...

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Bibliografiske detaljer
Main Authors: Almeida, Deepak, Nuermberger, Eric, Tasneen, Rokeya, Rosenthal, Ian, Tyagi, Sandeep, Williams, Kathy, Peloquin, Charles, Grosset, Jacques
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764177/
https://ncbi.nlm.nih.gov/pubmed/19620331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00830-09
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