Impact of Clofazimine Dosing on Treatment Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis

The antileprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment shortening when added to the first-line regimen for drug-susceptible tuberculosis in a mouse model. However, clofazimi...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Ammerman, Nicole C., Swanson, Rosemary V., Bautista, Elaine M., Almeida, Deepak V., Saini, Vikram, Omansen, Till F., Guo, Haidan, Chang, Yong Seok, Li, Si-Yang, Tapley, Asa, Tasneen, Rokeya, Tyagi, Sandeep, Betoudji, Fabrice, Moodley, Chivonne, Ngcobo, Bongani, Pillay, Logan, Bester, Linda A., Singh, Sanil D., Chaisson, Richard E., Nuermberger, Eric, Grosset, Jacques H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021677/
https://ncbi.nlm.nih.gov/pubmed/29735562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00636-18
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