Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis

The antileprosy drug clofazimine has shown potential for shortening tuberculosis treatment; however, the current dosing of the drug is not evidence based, and the optimal dosing is unknown. Our objective was to conduct a preclinical evaluation of the pharmacokinetics and pharmacodynamics of clofazim...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Swanson, Rosemary V., Adamson, John, Moodley, Chivonne, Ngcobo, Bongani, Ammerman, Nicole C., Dorasamy, Afton, Moodley, Sashen, Mgaga, Zinhle, Tapley, Asa, Bester, Linda A., Singh, Sanil, Grosset, Jacques H., Almeida, Deepak V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432183/
https://ncbi.nlm.nih.gov/pubmed/25753644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00260-15
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