Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis

The antileprosy drug clofazimine has shown potential for shortening tuberculosis treatment; however, the current dosing of the drug is not evidence based, and the optimal dosing is unknown. Our objective was to conduct a preclinical evaluation of the pharmacokinetics and pharmacodynamics of clofazim...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Swanson, Rosemary V., Adamson, John, Moodley, Chivonne, Ngcobo, Bongani, Ammerman, Nicole C., Dorasamy, Afton, Moodley, Sashen, Mgaga, Zinhle, Tapley, Asa, Bester, Linda A., Singh, Sanil, Grosset, Jacques H., Almeida, Deepak V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432183/
https://ncbi.nlm.nih.gov/pubmed/25753644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00260-15
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