Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis

The antileprosy drug clofazimine has shown potential for shortening tuberculosis treatment; however, the current dosing of the drug is not evidence based, and the optimal dosing is unknown. Our objective was to conduct a preclinical evaluation of the pharmacokinetics and pharmacodynamics of clofazim...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Swanson, Rosemary V., Adamson, John, Moodley, Chivonne, Ngcobo, Bongani, Ammerman, Nicole C., Dorasamy, Afton, Moodley, Sashen, Mgaga, Zinhle, Tapley, Asa, Bester, Linda A., Singh, Sanil, Grosset, Jacques H., Almeida, Deepak V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Experimental Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432183/
https://ncbi.nlm.nih.gov/pubmed/25753644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00260-15
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