Rifapentine Is Not More Active than Rifampin against Chronic Tuberculosis in Guinea Pigs

Rifamycins are key sterilizing drugs in the current treatment of active tuberculosis (TB). Daily dosing of rifapentine (P), a potent rifamycin with high intracellular accumulation, in place of rifampin (R) in the standard antitubercular regimen significantly shortens the duration of treatment needed...

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Autori principali: Dutta, Noton K., Illei, Peter B., Peloquin, Charles A., Pinn, Michael L., Mdluli, Khisimuzi E., Nuermberger, Eric L., Grosset, Jacques H., Karakousis, Petros C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393407/
https://ncbi.nlm.nih.gov/pubmed/22547623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00500-12
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